亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Diverse genetic conflicts mediated by molecular mimicry and computational approaches to detect them

生物 模仿 基因组 进化生物学 分子模拟 基因组学 遗传学 分子进化 遗传(遗传算法) 人口 孟德尔遗传 机制(生物学) 计算生物学 基因 生态学 哲学 人口学 认识论 抗原 社会学
作者
Shelbi L. Russell,Gabriel Penunuri,Christopher Condon
出处
期刊:Seminars in Cell & Developmental Biology [Elsevier BV]
卷期号:165: 1-12
标识
DOI:10.1016/j.semcdb.2024.07.001
摘要

In genetic conflicts between intergenomic and selfish elements, driver and killer elements achieve biased survival, replication, or transmission over sensitive and targeted elements through a wide range of molecular mechanisms, including mimicry. Driving mechanisms manifest at all organismal levels, from the biased propagation of individual genes, as demonstrated by transposable elements, to the biased transmission of genomes, as illustrated by viruses, to the biased transmission of cell lineages, as in cancer. Targeted genomes are vulnerable to molecular mimicry through the conserved motifs they use for their own signaling and regulation. Mimicking these motifs enables an intergenomic or selfish element to control core target processes, and can occur at the sequence, structure, or functional level. Molecular mimicry was first appreciated as an important phenomenon more than twenty years ago. Modern genomics technologies, databases, and machine learning approaches offer tremendous potential to study the distribution of molecular mimicry across genetic conflicts in nature. Here, we explore the theoretical expectations for molecular mimicry between conflicting genomes, the trends in molecular mimicry mechanisms across known genetic conflicts, and outline how new examples can be gleaned from population genomic datasets. We discuss how mimics involving short sequence-based motifs or gene duplications can evolve convergently from new mutations. Whereas, processes that involve divergent domains or fully-folded structures occur among genomes by horizontal gene transfer. These trends are largely based on a small number of organisms and should be reevaluated in a general, phylogenetically independent framework. Currently, publicly available databases can be mined for genotypes driving non-Mendelian inheritance patterns, epistatic interactions, and convergent protein structures. A subset of these conflicting elements may be molecular mimics. We propose approaches for detecting genetic conflict and molecular mimicry from these datasets.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
20秒前
爱思考的小笨笨完成签到,获得积分10
56秒前
GingerF应助科研通管家采纳,获得50
1分钟前
GingerF应助科研通管家采纳,获得50
1分钟前
上官若男应助闫雪采纳,获得10
1分钟前
1分钟前
1分钟前
Akitten发布了新的文献求助10
1分钟前
1分钟前
大写的LV完成签到 ,获得积分10
2分钟前
ffff完成签到 ,获得积分10
2分钟前
zsmj23完成签到 ,获得积分0
2分钟前
Owen应助科研通管家采纳,获得10
3分钟前
Owen应助hongtao采纳,获得10
3分钟前
3分钟前
哈哈哈完成签到 ,获得积分10
3分钟前
4分钟前
liu完成签到 ,获得积分10
4分钟前
33发布了新的文献求助10
4分钟前
4分钟前
阿金啊发布了新的文献求助10
4分钟前
科研通AI2S应助Cong采纳,获得10
4分钟前
科目三应助科研通管家采纳,获得10
5分钟前
5分钟前
5分钟前
务实书包发布了新的文献求助10
5分钟前
5分钟前
5分钟前
十三完成签到,获得积分10
5分钟前
积极的台灯应助某某某采纳,获得10
5分钟前
十三发布了新的文献求助10
5分钟前
5分钟前
tlh完成签到 ,获得积分10
5分钟前
直觉应助阿金啊采纳,获得30
6分钟前
6分钟前
6分钟前
6分钟前
hongtao发布了新的文献求助10
6分钟前
6分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990219
求助须知:如何正确求助?哪些是违规求助? 3532146
关于积分的说明 11256472
捐赠科研通 3271042
什么是DOI,文献DOI怎么找? 1805190
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809234