医学
呼吸窘迫
肺表面活性物质
胎粪吸入综合征
新生儿重症监护室
重症监护室
肺炎
呼吸衰竭
插管
表面活性剂疗法
麻醉
重症监护
儿科
胎粪
重症监护医学
内科学
胎龄
怀孕
胎儿
物理
遗传学
生物
热力学
作者
SENEM ALKAN ÖZDEMİR,ÖZLEM YILMAN,Şebnem Çalkavur,TÜLİN GÖKMEN YILDIRIM
出处
期刊:Turkish Journal of Medical Sciences
[Scientific and Technological Research Council of Turkey]
日期:2022-01-01
卷期号:52 (6): 1779-1784
被引量:4
标识
DOI:10.55730/1300-0144.5523
摘要
We aimed to discuss term infants who are given surfactant due to respiratory disorder according to the underlying etiology, the dose of surfactant administration, and the need for repeated surfactant administration.In this retrospective study infants hospitalized in the 4th level neonatal intensive care unit during January 2019 and December 2021 and administered surfactant due to respiratory distress were included. Term infants given surfactant due to respiratory failure were included in the study through the data recording system. The number of surfactant doses, indications for administration, mortality, duration of hospitalization, intubation time, and inotrope use were recorded in the infants included in the study.: During the two-year period, 1250 infants were hospitalized in our neonatal intensive care unit. Of those, 56 infants received surfactant replacement therapy for severe respiratory failure. There were 30 infants with pneumonia, 4 infants with meconium aspiration syndrome (MAS), and 22 infants with transient tachypnea of the newborn (TTN). It was seen that single-dose administration was higher in patients with TTN (p = 0.01), while multiple-dose surfactant administration was more common in patients with MAS, resulting in a statistical difference (p = 0.02). Mortality was lower, especially in cases given early surfactant administration and this situation was statistically significant (p < 0.001). Duration of intubation was 5.05 ± 4.7 days in early surfactant administration group and 8.0 ± 6.1 days in late surfactant administration group. This difference was statistically significant (p = 0.04). While early surfactant application was statistically higher in the TTN group (p = 0.007), late surfactant application was statistically higher in the pneumonia group (p = 0.001).Despite the difference on administration time and repeat dose interval due to etiology, surfactant treatment is improving the respiratory distress of term infants.
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