1‐(2′‐hydroxy‐2′‐methylpropionyl)glycoside as a versatile glycosyl donor for O‐/C‐glycosylation

Abstract Herein, we developed a Lewis acid‐mediated O ‐glycosylation and C ‐glycosylation protocol using stable glycosyl 2’‐hydroxy‐2’‐methylpropionates as donors. These glycosylation reactions reached completion within 1 h at room temperature. The practicality of this protocol is characterized by their straightforward operation and efficient applicability to various substrates, including both disarmed and armed glycosyl donors, through the remote activation of easily accessible TMSOTf.