材料科学
共价键
骨形成
过程(计算)
再生(生物学)
生物医学工程
计算机科学
化学
细胞生物学
工程类
医学
有机化学
生物
内分泌学
操作系统
作者
Ningtao Wang,Jie Chen,Yanyang Chen,Liang Chen,Luhan Bao,Zhengmei Huang,Xiaoyu Han,Jiangkuo Lu,Zhengwei Cai,Wenguo Cui,Zhengwei Huang
标识
DOI:10.1016/j.bioactmat.2024.06.021
摘要
Irregular bone defects, characterized by unpredictable size, shape, and depth, pose a major challenge to clinical treatment. Although various bone grafts are available, none can fully meet the repair needs of the defective area. Here, this study fabricates a dough-type hydrogel (DR-Net), in which the first dynamic network is generated by coordination between thiol groups and silver ions, thereby possessing kneadability to adapt to various irregular bone defects. The second rigid covalent network is formed through photocrosslinking, maintaining the osteogenic space under external forces and achieving a better match with the bone regeneration process.
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