Asymmetric construction of enantioenriched furo[2,3-b]pyridines through sequential gold, palladium/phosphoric acid catalysis

A multi-catalytic system combining gold, palladium and phosphoric acid was applied for asymmetric assembly of ynamides and carbonate of 4-hydroxy-2-cyclopentenone, furnishing furo[2,3- b ]pyridines in high yields and stereoselectivities.