喘息
哮喘
医学
体质指数
儿科
遗传倾向
队列
呼吸音
队列研究
呼吸道感染
风险因素
内科学
呼吸系统
疾病
作者
Signe Kjeldgaard Jensen,Casper‐Emil Tingskov Pedersen,Kasper Fischer-Rasmussen,Mathias Elsner Melgaard,Nicklas Brustad,Julie Nyholm Kyvsgaard,Nilo Vahman,Ann‐Marie Malby Schoos,Jakob Stokholm,Julie Nyholm Kyvsgaard,Anders U. Eliasen,Klaus Bønnelykke
出处
期刊:The European respiratory journal
[European Respiratory Society]
日期:2024-05-29
卷期号:: 2400169-2400169
标识
DOI:10.1183/13993003.00169-2024
摘要
Background High BMI is an established risk factor for asthma, but the underlying mechanisms remain unclear. Objective: To increase understanding of the BMI-asthma relationship by studying the association between genetic predisposition to higher body mass index (BMI) and asthma, infections, and other asthma-traits during childhood. Methods Data was obtained from the two ongoing COPSAC mother-child cohorts. Polygenic risk score (PRS) for adult BMI were calculated for each child. Replication was done in the large-scale iPSYCH cohort using data on hospitalization for asthma and infections. Results In the COPSAC cohorts (n=974), the adult BMI PRS was significantly associated with lower respiratory tract infections (LRTI) (IRR 1.20 95% CI 1.08–1.33, FDR=0.005) age 0–3 years and episodes of severe wheeze (IRR 1.30, 1.06–1.60, FDR=0.04) age 0–6 years. LRTI partly mediated the association between the adult BMI PRS and severe wheeze (proportion mediated: 0.59, 0.28–2.24, pACME 2E-16). In contrast, these associations were not mediated through the child's current BMI and the PRS was not associated with an asthma diagnosis or reduced lung function up to age 18. The associations were replicated in iPSYCH (n=114 283), where the adult BMI PRS significantly increased the risk of hospitalizations for LRTI and wheeze or asthma during childhood to age 18 years. Conclusion Children with genetic predisposition to higher BMI had increased risk of LRTI and severe wheeze, independent of the child's current BMI. These results shed further light on the complex relationship between BMI and asthma.
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