Prioritization of Drug Targets for Neurodegenerative Diseases by Integrating Genetic and Proteomic Data From Brain and Blood

医学痴呆疾病肌萎缩侧索硬化失智症全基因组关联研究路易体孟德尔随机化生物信息学生物内科学单核苷酸多态性遗传学基因基因型遗传变异

作者

Yi‐Jun Ge,Ya‐Nan Ou,Yue‐Ting Deng,Bang‐Sheng Wu,Yang Liu,Ya-Ru Zhang,Shi-Dong Chen,Yu‐Yuan Huang,Qiang Dong,Lan Tan,Jin‐Tai Yu,Raffaele Maletta,Allan I. Levey,Michael E. Weale,Jonathan D. Rohrer,Adaikalavan Ramasamy,John B. Kwok,Carol Dobson‐Stone,William S. Brooks,Peter R. Schofield,Glenda M. Halliday,John R. Hodges,Olivier Piguet,Lauren Bartley,Elizabeth Thompson,Eric Haan,Isabel Hernández,Agustı́n Ruiz,Merçé Boada,Barbara Borroni,Alessandro Padovani,Carlos Cruchaga,Nigel J. Cairns,Luisa Benussi,Giuliano Binetti,Roberta Ghidoni,Gianluigi Forloni,Daniela Galimberti,Chiara Fenoglio,María Serpente,Elio Scarpini,Jordi Clarimón,Alberto Lleó,Rafael Blesa,María Serpente,Karin Nilsson,Christer Nilsson,Ian R. Mackenzie,Ging‐Yuek Robin Hsiung,David Mann,Jordan Grafman,Christopher M. Morris,Johannes Attems,Timothy D. Griffiths,Ian G. McKeith,Alan Thomas,Pietro Pietrini,Edward D. Huey,Eric M. Wassermann,Atik Baborie,Evelyn Jaros,Michael Tierney,Pau Pástor,Cristina Razquín,Sara Rollinson,Elena Alonso,Robert Perneczky,Janine Diehl‐Schmid,Panagiotis Alexopoulos,Alexander Kurz,Innocenzo Rainero,Elisa Rubino,Lorenzo Pinessi,Ekaterina Rogaeva,Peter St George–Hyslop,Giacomina Rossi,Fabrizio Tagliavini,Giorgio Giaccone,James B. Rowe,J Schlachetzki,Thor Aspelund,Simon Mead,Simon Mead,Adrian Danek,Vivianna M. Van Deerlin,Murray Grossman,John Q. Trojanowski,Julie S. Snowden,William Deschamps,Tim Van Langenhove,Marc Cruts,Christine Van Broeckhoven,Stefano F. Cappa,Isabelle Le Ber,Didier Hannequin,Véronique Golfier,Martine Vercelletto,Alexis Brice,Benedetta Nacmias,Sandro Sorbi,Silvia Bagnoli,Irene Piaceri,Jørgen E. Nielsen,Lena E. Hjermind,Markus J. Riemenschneider,Manuel Mayhaus,Bernd Ibach,Gilles Gasparoni,Sabrina Pichler,Wei Gu,Martin N. Rossor,Nick C. Fox,Jason D. Warren,Maria Grazia Spillantini,Huw R. Morris,Patrizia Rizzu,Peter Heutink,Julie S. Snowden,Sara Rollinson,Anna E. Jeffreys,Alexander Gerhard,Amalia C. Bruni,Raffaele Maletta,Francesca Frangipane,Chiara Cupidi,Livia Bernardi,Maria Anfossi,Maura Gallo,Maria Elena Conidi,Nicoletta Smirne,Rosa Rademakers,Matt Baker,Dennis W. Dickson,Caroline Graff,Peter Heutink,David S. Knopman,Keith A. Josephs,Bradley F. Boeve,Joseph E. Parisi,William W. Seeley,Bruce L. Miller,Anna M. Karydas,Yoav Ben‐Shlomo,John C. van Swieten,Elise G.P. Dopper,Harro Seelaar,Yolande A.L. Pijnenburg,Philip Scheltens,Giancarlo Logroscino,Rosa Capozzo,Valeria Novelli,Annibale Alessandro Puca,M. Franceschi,Alfredo Postiglione,Graziella Milan,Paolo Sorrentino,Mark Kristiansen,Huei‐Hsin Chiang,Caroline Graff,Florence Pasquier,Adeline Rollin,Vincent Deramecourt,Florence Lebert,Dimitrios Kapogiannis,Luigi Ferrucci,Stuart Pickering‐Brown,Andrew Singleton,John Hardy,Parastoo Momeni

出处

期刊：Biological Psychiatry [Elsevier]
日期：2022-11-09 卷期号：93 (9): 770-779 被引量：15

链接

ac.uk ac.uk ac.uk nih.govdoi.org

标识

DOI：10.1016/j.biopsych.2022.11.002

摘要

Neurodegenerative diseases are among the most prevalent and devastating neurological disorders, with few effective prevention and treatment strategies. We aimed to integrate genetic and proteomic data to prioritize drug targets for neurodegenerative diseases.

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Prioritization of Drug Targets for Neurodegenerative Diseases by Integrating Genetic and Proteomic Data From Brain and Blood

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