姜黄素
化学
超分子化学
堆积
氨基酸
组合化学
生物物理学
药品
生物化学
药理学
有机化学
分子
生物
作者
Yongxin Li,Qianli Zou,Chengqian Yuan,Shukun Li,Ruirui Xing,Xuehai Yan
标识
DOI:10.1002/anie.201810087
摘要
Abstract Clinical translation of curcumin has been highly obstructed by the rapid degradation and poor tissue absorption of this agent. Herein, we report on the generation of supramolecular curcumin nanoagents through amino acid coordination driven self‐assembly to simultaneously increase the biological stability and tumor accumulation of curcumin. The biological stability of curcumin was significantly improved both through coordination and through molecular stacking. The sizes of these nanoagents can be readily manipulated to facilitate tumor accumulation. These favorable therapeutic features, together with high drug‐loading capacities and responses to pH and redox stimuli, substantially enhanced the antitumor activity of curcumin without discernible side effects. Hence, supramolecular curcumin nanoagents may hold promise in moving forward the clinical application of curcumin as an effective anticancer drug.
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