Slc26 Family of Anion Transporters in the Gastrointestinal Tract: Expression, Function, Regulation, and Role in Disease

基因亚型 运输机 溶质载体族 生物化学 氯离子通道 化学 潘特林 生物 细胞生物学 基因
作者
Ursula Seidler,Katerina Nikolovska
出处
期刊:Comprehensive Physiology [Wiley]
卷期号:: 839-872 被引量:51
标识
DOI:10.1002/cphy.c180027
摘要

ABSTRACT SLC26 family members are multifunctional transporters of small anions, including Cl − , HCO 3 − , sulfate, oxalate, and formate. Most SLC26 isoforms act as secondary (coupled) anion transporters, while others mediate uncoupled electrogenic transport resembling Cl − channels. Of the 11 described SLC26 isoforms, the SLC26A1,2,3,6,7,9,11 are expressed in the gastrointestinal tract, where they participate in salt and water transport, surface pH‐microclimate regulation, affect the microbiome composition, the absorption, and secretion of oxalate and sulfate, and other functions that require further study. Several intestinal or extra‐intestinal diseases are related to SLC26A mutations. Patients with congenital chloride diarrhea (CLD) suffer from Cl − ‐rich acidic diarrhea and systemic alkalosis due to SLC26A3 mutations. Patients with osteochondrodysplastic syndromes experience skeletal defects due to SLC26A2 mutations, resulting in defective sulfate absorption in enterocytes and sulfate uptake in chondrocytes. Because of functional interactions between SLC26 and other proteins, such as the Cl − channel CFTR, some of the intestinal cystic fibrosis manifestations may be attributed to impaired SLC26 isoform localization and function. The altered expression of SLC26 members due to inflammation or operative procedures have important consequences on intestinal transport and barrier function in common diseases as inflammatory bowel disease or bariatric surgery. The present review gives an overview on the current state of knowledge of the intestinally expressed SLC26A isoforms (SLC26A1,2,3,6,7,9,11) from the history of their functional identification, cloning and expression, the insights into their function, interaction partners and regulation gained in heterologous expression systems and Slc26a‐deficient mice, to information about their transcriptional regulation and roles in gastrointestinal disease manifestations. © 2019 American Physiological Society. Compr Physiol 9:839‐872, 2019.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
TLDX完成签到,获得积分10
1秒前
飒飒发布了新的文献求助10
1秒前
HH发布了新的文献求助30
3秒前
大橙子发布了新的文献求助10
4秒前
5秒前
月月完成签到,获得积分10
5秒前
5秒前
哆啦A梦完成签到,获得积分10
6秒前
了尘完成签到,获得积分10
7秒前
wangnn发布了新的文献求助10
8秒前
量子星尘发布了新的文献求助10
8秒前
体贴的叛逆者完成签到,获得积分10
9秒前
幸福的鑫鹏完成签到,获得积分10
9秒前
孤海未蓝完成签到,获得积分10
10秒前
彭于晏应助飒飒采纳,获得10
11秒前
狠毒的小龙虾完成签到,获得积分10
12秒前
小趴菜完成签到,获得积分10
16秒前
lcls完成签到,获得积分10
17秒前
17秒前
18秒前
尊敬太阳发布了新的文献求助10
20秒前
风中夜天完成签到 ,获得积分10
20秒前
优雅友蕊完成签到,获得积分10
21秒前
gaga完成签到,获得积分10
22秒前
西北孤傲的狼完成签到,获得积分10
23秒前
多边形完成签到 ,获得积分10
25秒前
李cc完成签到,获得积分10
27秒前
27秒前
快帮我找找完成签到,获得积分10
27秒前
xiezhuochun完成签到 ,获得积分10
28秒前
31秒前
aixiaoming0503完成签到,获得积分10
32秒前
forge完成签到,获得积分10
32秒前
33秒前
Distance完成签到,获得积分10
36秒前
蒋念寒发布了新的文献求助10
37秒前
雪雨夜心完成签到,获得积分10
41秒前
又是一年完成签到,获得积分10
42秒前
Distance发布了新的文献求助10
43秒前
李子完成签到 ,获得积分10
44秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038184
求助须知:如何正确求助?哪些是违规求助? 3575908
关于积分的说明 11373872
捐赠科研通 3305715
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022