Contrast-enhanced ultrasound imaging of atherosclerotic carotid plaque neovascularization: a new surrogate marker of atherosclerosis?

血管 新生血管 医学 含铁血黄素 川地31 颈动脉内膜切除术 病理 血管生成 动脉内膜切除术 川地34 血管性血友病因子 血管内皮生长因子 放射科 内科学 颈动脉 干细胞 血小板 血管内皮生长因子受体 生物 遗传学
作者
Falak Shah,Prakash Balan,Matthew Weinberg,Vijaya B. Reddy,Rachel Neems,Matthew J. Feinstein,John R. Dainauskas,Peter Meyer,Marshall D. Goldin,Steven B. Feinstein
出处
期刊:Vascular Medicine [SAGE]
卷期号:12 (4): 291-297 被引量:198
标识
DOI:10.1177/1358863x07083363
摘要

An atherosclerotic plaque requires a nutrient blood supply, which is predominantly derived from arterial vasa vasorum. A variety of factors (environmental and genetic) contribute to the initiation and growth of atherosclerosis within vessel walls. Chemotactic factors, such as tissue ischemic and hypoxic factors, stimulate the release of vascular endothelial growth factor (VEGF) proteins, resulting in vessel wall angiogenesis. These developments often precede the formation of the luminal plaque. In this report, we describe the use of contrast-enhanced carotid ultrasound (CECU) imaging for the detection and quantification of intra-plaque neovascularization. The efficacy of CECU was measured against the neovascular density observed within the tissue specimens obtained at the time of carotid endarterectomy surgery. The objective of this study was to provide a histologic correlation between CECU and carotid artery atherosclerotic plaque neovascularization. Fifteen patients with significant atherosclerotic carotid artery disease received a CECU examination prior to undergoing a carotid endarterectomy (CEA). Two patients received bilateral endarterectomies, resulting in a total of 17 cases. At the time of surgery, carotid plaque samples were surgically removed and stained with specific vascular markers (CD31, CD34, von Willebrand factor, and hemosiderin) designed to identify the presence and degree of neovascularization. The intra-plaque neovascularization recorded on preoperative CECU was correlated with the degree of neovascularization noted in the tissue specimens. The CECU neovascularization was correlated to CD31-stained tissue specimens. This correlation value was 0.68 using Spearman's rank method. When CECU results were correlated with the other histologic markers (CD34, von Willebrand factor, and hemosiderin), a correlation of 0.50 was obtained. In conclusion, contrast-enhanced carotid ultrasound correlated to the presence and degree of intra-plaque neovascularization as determined from histology specimens.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
1秒前
2秒前
李大了发布了新的文献求助20
3秒前
小鳄鱼夸夸完成签到,获得积分10
4秒前
4秒前
6秒前
7秒前
7秒前
8秒前
8秒前
10秒前
我叫预言家完成签到,获得积分20
11秒前
武雨寒发布了新的文献求助10
12秒前
HJ002发布了新的文献求助10
15秒前
高挑的果汁完成签到,获得积分10
18秒前
22秒前
英姑应助sxy采纳,获得10
23秒前
李健的小迷弟应助jack采纳,获得10
23秒前
23秒前
Yakamoz发布了新的文献求助10
24秒前
26秒前
27秒前
liuxc完成签到 ,获得积分10
27秒前
上官若男应助哈库丹采纳,获得10
27秒前
27秒前
晗月完成签到,获得积分10
28秒前
Emmmm发布了新的文献求助10
28秒前
29秒前
30秒前
Strike发布了新的文献求助10
30秒前
31秒前
欢喜的小天鹅完成签到 ,获得积分10
31秒前
czp完成签到,获得积分10
31秒前
Dmumu完成签到,获得积分10
32秒前
Akim应助小绵羊采纳,获得10
33秒前
田様应助小绵羊采纳,获得10
33秒前
33秒前
czp发布了新的文献求助10
34秒前
彩虹马发布了新的文献求助10
34秒前
高分求助中
좌파는 어떻게 좌파가 됐나:한국 급진노동운동의 형성과 궤적 2500
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Cognitive linguistics critical concepts in linguistics 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
氟盐冷却高温堆非能动余热排出性能及安全分析研究 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3051899
求助须知:如何正确求助?哪些是违规求助? 2709225
关于积分的说明 7416342
捐赠科研通 2353554
什么是DOI,文献DOI怎么找? 1245569
科研通“疑难数据库(出版商)”最低求助积分说明 605799
版权声明 595870