韧皮部
化学
根皮苷
细胞培养
癌细胞
细胞生长
癌症
生物化学
立体化学
生物
内科学
葡萄糖转运蛋白
内分泌学
医学
遗传学
胰岛素
作者
Xiaoxiao Qin,Sai-Yang Xie,Zhiqin Zhou,Yuncong Yao
出处
期刊:Molecules
[MDPI AG]
日期:2015-11-27
卷期号:20 (12): 21193-21203
被引量:73
标识
DOI:10.3390/molecules201219754
摘要
Seven dihydrochalcone compounds were isolated from the leaves of Malus crabapples, cv. “Radiant”, and their chemical structures were elucidated by UV, IR, ESI-MS, 1H-NMR and 13C-NMR analyses. These compounds, which include trilobatin (A1), phloretin (A2), 3-hydroxyphloretin (A3), phloretin rutinoside (A4), phlorizin (A5), 6′′-O-coumaroyl-4′-O-glucopyranosylphloretin (A6), and 3′′′-methoxy-6′′-O-feruloy-4′-O-glucopyranosyl-phloretin (A7), all belong to the phloretin class and its derivatives. Compounds A6 and A7 are two new rare dihydrochalcone compounds. The results of a MTT cancer cell growth inhibition assay demonstrated that phloretin and these derivatives showed significant positive anticancer activities against several human cancer cell lines, including the A549 human lung cancer cell line, Bel 7402 liver cancer cell line, HepG2 human ileocecal cancer cell line, and HT-29 human colon cancer cell line. A7 had significant effects on all cancer cell lines, suggesting potential applications for phloretin and its derivatives. Adding a methoxyl group to phloretin dramatically increases phloretin’s anticancer activity.
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