泛素连接酶
泛素
细胞生物学
亚细胞定位
降级(电信)
细胞质
脂质代谢
生物化学
化学
生物
基因
计算机科学
电信
作者
Kenji Ishimoto,Ayaka Hayase,Fumiko Kumagai,Megumi Kawai,Hiroko Okuno,Nobumasa Hino,Yoshiaki Okada,Takashi Kawamura,Toshiya Tanaka,Takao Hamakubo,Juro Sakai,Tatsuhiko Kodama,Keisuke Tachibana,Takefumi Doi
标识
DOI:10.1016/j.bbrc.2017.04.159
摘要
Lipin-1 has dual functions in the regulation of lipid and energy metabolism according to its subcellular localization, which is tightly controlled. However, it is unclear how Lipin-1 degradation is regulated. Here, we demonstrate that Lipin-1 is degraded through its DSGXXS motif. We show that Lipin-1 interacts with either of two E3 ubiquitin ligases, BTRC or FBXW11, and that this interaction is DSGXXS-dependent and mediates the attachment of polyubiquitin chains. Further, we demonstrate that degradation of Lipin-1 is regulated by BTRC in the cytoplasm and on membranes. These novel insights into the regulation of human Lipin-1 stability will be useful in planning further studies to elucidate its metabolic processes.
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