金融时报
踏步
细胞分裂
微管蛋白
GTP酶
细胞生物学
微管
生物
细胞
细胞骨架
化学
埃布先生
细胞壁
胞质分裂
细菌细胞结构
肽聚糖
生物化学
细菌
遗传学
微丝
作者
Xinxing Yang,Zhixin Lyu,Amanda Miguel,Ryan McQuillen,Kerwyn Casey Huang,Jie Xiao
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2017-02-17
卷期号:355 (6326): 744-747
被引量:368
标识
DOI:10.1126/science.aak9995
摘要
The bacterial tubulin FtsZ is the central component of the cell division machinery, coordinating an ensemble of proteins involved in septal cell wall synthesis to ensure successful constriction. How cells achieve this coordination is unknown. We found that in Escherichia coli cells, FtsZ exhibits dynamic treadmilling predominantly determined by its guanosine triphosphatase activity. The treadmilling dynamics direct the processive movement of the septal cell wall synthesis machinery but do not limit the rate of septal synthesis. In FtsZ mutants with severely reduced treadmilling, the spatial distribution of septal synthesis and the molecular composition and ultrastructure of the septal cell wall were substantially altered. Thus, FtsZ treadmilling provides a mechanism for achieving uniform septal cell wall synthesis to enable correct polar morphology.
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