斯达
JAK-STAT信号通路
癌症研究
STAT蛋白
信号转导
个人识别码1
骨髓增生性肿瘤
贾纳斯激酶
骨髓增生性疾病
造血
Janus激酶2
髓样
白血病
生物
免疫学
医学
车站3
骨髓纤维化
磷酸化
细胞生物学
骨髓
酪氨酸激酶
干细胞
丝氨酸
作者
Yaling Zhao,Gui-Min Liu,Qian Zhang,Wentong Liang,Zhiyong Cheng
出处
期刊:PubMed
日期:2016-08-01
卷期号:24 (4): 1275-9
被引量:1
标识
DOI:10.7534/j.issn.1009-2137.2016.04.059
摘要
Jauns kinase (JAK)/transducer and activator of transcription(STAT) pathway is a classical approach to study the rapid changes of the gene expression in specific target cells by a variety of extracellular signals. The JAK and STAT transfer cytokine receptor signaling plays a unique role in multiple cellular and molecular biological changes.The abnormal signal of JAK/STAT pathway will lead to the hematopoietic abnormalities.Studies had shown that the abnormal activation of JAK2/STAT signaling pathway are in many kinds of malignant hematological diseases, such as in acute lymphoblastic/myeloid leukemia, chronic myeloid leukemia, lymphoma, myelodysplastic syndromes, myeloprofilerative neoplasm, especially in the patients of myeloproliferative neoplasm(MPN) with JAK gene mutation(JAK2V617F), this mutation has an important value for MPN diagnosis. At present, the effect of the specific inhibitors of JAK2 has showed good perspective, which had been applied to clinic treatment and achieved remarkable curative effect. In this review, the JAK2/STAT signaling transduction, the JAK2 signal and hematologic malignancies, the kagulation of signaling pathway and the inhibitors of JAK2/STAT signaling pathway are summarized.
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