背景(考古学)
临床试验
医学
神经科学
药物发现
计算生物学
计算机科学
生物信息学
生物
古生物学
作者
Daniela N. Rocha,Eva D. Carvalho,Ana Paula Pêgo
标识
DOI:10.1016/j.drudis.2016.05.005
摘要
Despite the recent progress in the understanding of neurodegenerative disorders, a lack of solid fundamental knowledge on the etiology of many of the major neurodegenerative diseases has made it difficult to obtain effective therapies to treat these conditions. Scientists have been looking to carry out more-human-relevant studies, with strong statistical power, to overcome the limitations of preclinical animal models that have contributed to the failure of numerous therapeutics in clinical trials. Here, we identify currently existing platforms to mimic central nervous system tissues, healthy and diseased, mainly focusing on cell-based platforms and discussing their strengths and limitations in the context of the high-throughput screening of new therapeutic targets and drugs.
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