生物
组织向性
向性
免疫系统
麻疹病毒
受体
病毒
病毒学
麻疹病毒
细胞生物学
免疫学
副粘病毒科
接种疫苗
生物化学
麻疹
病毒性疾病
作者
Jürgen Schneider‐Schaulies,Sibylle Schneider‐Schaulies
出处
期刊:Advances in Virus Research
日期:2008-01-01
卷期号:: 173-205
被引量:33
标识
DOI:10.1016/s0065-3527(08)00004-3
摘要
Induction of immunomodulation and ‐suppression is a common feature of morbilliviruses such as measles virus (MV), rinderpest virus (RPV), and canine distemper virus (CDV) in their respective hosts. As major uptake receptor, signaling lymphocytic activation molecule (SLAM, CD150) essentially determines their tropism for immune cells, which is of considerable importance with regard to immunosuppression and the systemic spread to organs including secondary lymphoid organs, the skin, the respiratory tract, and the brain. Independent of their ability to enhance virus uptake in specialized host cells, other cell surface receptors such as the substance P receptor, DC‐SIGN, Toll‐like receptors (TLR), Fc‐gamma receptor II (FcγRII), CD46, and additional uncharacterized receptors exert a variety of immunomodulatory effects as reflected by activation of or interference with viability, differentiation, trafficking, or acquisition of effector functions of specialized immune cells. In this review, we discuss receptor interactions, tropism, and mechanisms involved in the severe, transient immunosuppression induced by MV and other morbilliviruses.
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