Backround: Rosa damascena Mill, released into the environment as waste in rose products production facilities, contains antioxidant, antimicrobial, and antiseptic phenolic components. It is the development of an effective natural cream formulation for baby diaper rash by taking advantage of the antimicrobial properties of rose pulp and adding natural ingredients (zinc oxide ZnO, natural oils, and beeswax). Material and Methods: The emulsification method was used to prepare diaper rash cream formulations. Rotational type viscosity determination was performed to examine the rheological behavior of the formulations. In selecting the optimum formulation, pH, viscosity, hydrophilic-lipophilic balance, and physical appearance of the product were considered. To examine its stability properties, its stability was examined in three different environments in line with ICH directives for 6months. The optimum DR-C-7 formulation was subjected to physicochemical and stability tests. Results: It was observed that the DR-C-7 formulation had a viscosity between 9,820 and 26,130 (Pa.s) in terms of rheological properties. As a result of the challenge test, no microbiological units were found. At the end of a 6-month stability study under different conditions, it was observed that it retained all its features. Conclusion: It was concluded that R. damascena pulp, which has important phenolic contents such as phenylethyl alcohol, flavonoids, and terpenoids, can be used for thick products such as diaper rash cream with its antioxidant antimicrobial properties.