微流控
体内
生物医学工程
体外
纳米技术
计算机科学
材料科学
化学
生物
医学
生物技术
生物化学
作者
Zhenlin Chen,Lei Fan,Shuxun Chen,Han Zhao,Qiang Zhang,Yun Qu,Ya Huang,Xinge Yu,Dong Sun
标识
DOI:10.1002/adhm.202304532
摘要
Abstract In vitro blood vessel models are significant for disease modeling, drug assays, and therapeutic development. Microfluidic technologies allow to create physiologically relevant culture models reproducing the features of the in vivo vascular microenvironment. However, current microfluidic technologies are limited by impractical rectangular cross‐sections and single or nonsynchronous compound mechanical stimuli. This study proposes a new strategy for creating round‐shaped deformable soft microfluidic channels to serve as artificial in vitro vasculature for developing in vitro models with vascular physio‐mechanical microenvironments. Endothelial cells seeded into vascular models are used to assess the effects of a remodeled in vivo mechanical environment. Furthermore, a 3D stenosis model is constructed to recapitulate the flow disturbances in atherosclerosis. Soft microchannels can also be integrated into traditional microfluidics to realize multifunctional composite systems. This technology provides new insights into applying microfluidic chips and a prospective approach for constructing in vitro blood vessel models.
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