血管生成
再生(生物学)
生物材料
骨愈合
材料科学
生物医学工程
细胞生物学
癌症研究
外科
医学
生物
作者
Nannan Xue,Pei Liu,Wenjian Zhao,Ziyi Zhou,Lixiang Zhang,Rizhong Huang,Rui Liu,Ali Fathi,Jin‐Ao Duan,Jun Chen,Yiwei Wang
标识
DOI:10.1002/adhm.202304400
摘要
The management of critical-sized bone defects presents a formidable clinical challenge, especially given the increasing incidence of bone diseases in the aging population. Consequently, there is an increased demand for minimally invasive bone repair materials that can effectively address this challenge, particularly in outpatient settings. In this study, the goal is to develop an injectable and biodegradable biomaterial that adheres to and fills bone-defect sites to support bone regeneration. The osteogenic and angiogenic activities of animal horn peptides are investigated by incorporating them into biologically active moieties, in combination with a novel thermosensitive hydrogel. The resulting thermosensitive hydrogel exhibited essential biological functionalities, allowing precise modulation of its physical and chemical properties. Notably, the hydrogel incorporating the horn peptide rapidly filled the bone defect site, promoting both angiogenesis and bone induction. Consequently, this approach significantly accelerates new bone regeneration. In summary, the findings of this study present a promising, minimally invasive solution for addressing critical-sized bone defects.
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