The role of hormones in the regulation of lactogenic immunity in porcine and bovine species

激素 内科学 内分泌学 免疫 催乳素 生物 牛生长激素 化学 细胞生物学 免疫系统 生长激素 医学 免疫学
作者
Kexin Hua,Dan Liu,Qianshuai Xu,Yong Peng,Yukui Zhang,Rongrong He,Rongrong He,Hui Jin
出处
期刊:Domestic Animal Endocrinology [Elsevier]
卷期号:: 106851-106851
标识
DOI:10.1016/j.domaniend.2024.106851
摘要

Colostrum and milk offer a complete diet and vital immune protection for newborn mammals with developing immune systems. High immunoglobulin levels in colostrum serve as the primary antibody source for newborn piglets and calves. Subsequent milk feeding support continued local antibody protection against enteric pathogens, as well as maturation of the developing immune system and provide nutrients for newborn growth. Mammals have evolved hormonal strategies that modulate the levels of immunoglobulins in colostrum and milk to facilitate effective lactational immunity. In addition, hormones regulate the gut-mammary gland-secretory immunoglobulin A (sIgA) axis in pregnant mammals, controlling the levels of sIgA in milk, which serves as the primary source of IgA for piglets and helps them resist pathogens such as PEDV and TGEV. In the present study, we review the existing studies on the interactions between hormones and the gut-mammary-sIgA axis/lactogenic immunity in mammals and explore the potential mechanisms of hormonal regulation that have not been studied in detail, to draw attention to the role of hormones in influencing the immune response of pregnant and lactating mammals and their offspring, and highlight the effect of hormones in regulating sIgA-mediated anti-infection processes in colostrum and milk. Discussion of the relationship between hormones and lactogenic immunity may lead to a better way of improving lactogenic immunity by determining a better injection time and developing new vaccines.
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