Systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio in patients with type 2 diabetes at different stages of diabetic retinopathy

医学 中性粒细胞与淋巴细胞比率 糖尿病性视网膜病变 内科学 接收机工作特性 胃肠病学 糖尿病 优势比 淋巴细胞 置信区间 逻辑回归 2型糖尿病 曲线下面积 2型糖尿病 视网膜病变 多元分析 内分泌学
作者
Difei Lu,Chang-Lin Zhao,Chang-Lin Zhao,Chang-Lin Zhao,Meng Hu,Chang-Lin Zhao,Chang-Lin Zhao,Feng Yan,Qian Cao
出处
期刊:International Journal of Ophthalmology [Press of International Journal of Ophthalmology (IJO Press)]
卷期号:17 (5): 877-882
标识
DOI:10.18240/ijo.2024.05.12
摘要

AIM: To investigate systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) levels in patients with type 2 diabetes at different stages of diabetic retinopathy (DR). METHODS: This retrospective study included 141 patients with type 2 diabetes mellitus (DM): 45 without diabetic retinopathy (NDR), 47 with non-proliferative diabetic retinopathy (NPDR), and 49 with proliferative diabetic retinopathy (PDR). Complete blood counts were obtained, and NLR, PLR, and SII were calculated. The study analysed the ability of inflammatory markers to predict DR using receiver operating characteristic (ROC) curves. The relationships between DR stages and SII, PLR, and NLP were assessed using multivariate logistic regression. RESULTS: The average NLR, PLR, and SII were higher in the PDR group than in the NPDR group (P=0.011, 0.043, 0.009, respectively); higher in the NPDR group than in the NDR group (P<0.001 for all); and higher in the PDR group than in the NDR group (P<0.001 for all). In the ROC curve analysis, the NLR, PLR, and SII were significant predictors of DR (P<0.001 for all). The highest area under the curve (AUC) was for the PLR (0.929 for PLR, 0.925 for SII, and 0.821 for NLR). Multivariate regression analysis indicated that NLR, PLR, and SII were statistically significantly positive and independent predictors for the DR stages in patients with DM [odds ratio (OR)=1.122, 95% confidence interval (CI): 0.200–2.043, P<0.05; OR=0.038, 95%CI: 0.018–0.058, P<0.05; OR=0.007, 95%CI: 0.001–0.01, P<0.05, respectively). CONCLUSION: The NLR, PLR, and SII may be used as predictors of DR.
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