Human bocavirus respiratory infection: Tracing the path from viral replication and virus‐cell interactions to diagnostic methods

博卡病毒 毛细支气管炎 免疫学 肺炎 普通感冒 下呼吸道感染 病毒 呼吸道感染 鼻病毒 医学 呼吸系统 疾病 病因学 病毒学 生物 病理 内科学
作者
María Belén Colazo Salbetti,Gabriel Amilcar Boggio,Laura Moreno,María Pilar Adamo
出处
期刊:Reviews in Medical Virology [Wiley]
卷期号:33 (6) 被引量:2
标识
DOI:10.1002/rmv.2482
摘要

Abstract Human bocaviruses were first described between 2005 and 2010, identified in respiratory and enteric tract samples of children. Screening studies have shown worldwide distribution. Based on phylogenetic analysis, they were classified into four genotypes (HBoV1‐4). From a clinical perspective, human bocavirus 1 (HBoV1) is considered the most relevant, since it can cause upper and lower acute respiratory tract infection, mainly in infants, including common cold, bronchiolitis, and pneumonia, as well as wheezing in susceptible patients. However, the specific processes leading to structural, biochemical, and functional changes resulting in the different clinical presentations have not been elucidated yet. This review surveys the interactions between the virus and target cells that can potentially explain disease‐causing mechanisms. It also summarises the clinical phenotype of cases, stressing the role of HBoV1 as an aetiological agent of lower acute respiratory infection in infants, together with laboratory tests for detection and diagnosis. By exploring the current knowledge on the epidemiology of HBoV1, insights into the complex scenario of paediatric respiratory infections are presented, as well as the potential effects that changes in the circulation can have on the dynamics of respiratory agents, spotlighting the benefits of comprehensively increase insights into incidence, interrelationships with co‐circulating agents and potential control of HBoV1.
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