牙周炎
牙槽
医学
骨吸收
免疫系统
免疫学
平衡
吸收
牙科
病理
内科学
作者
Siyan Liu,Yingyi Chen,Yiyang Jiang,Juan Du,Lijia Guo,Junji Xu,Yitong Liu,Yi Liu
出处
期刊:Oral Diseases
[Wiley]
日期:2023-11-05
卷期号:30 (5): 2865-2875
被引量:2
摘要
Abstract Objective To evaluate the regulatory role of neutrophils as the first line of host immune defense in the periodontal microenvironment of mice. Methods A systematic search was performed using PubMed, Web of Science, and ScienceDirect databases for articles published between 2012 and 2023. In this review, articles investigating the effect of neutrophils on alveolar bone resorption in a mouse model of periodontitis were selected and evaluated according to eligibility criteria. Important variables that may influence outcomes were analyzed. Results Eleven articles were included in this systematic review. The results showed that because of their immune defense functions, the functional homeostasis of local neutrophils is critical for periodontal health. Neutrophil deficiency aggravates alveolar bone loss. However, several studies have shown that excessive neutrophil infiltration is positively correlated with alveolar bone resorption caused by periodontitis in mice. Therefore, the homeostasis of neutrophil function needs to be considered in the treatment of periodontitis. Conclusions Pooled analysis suggests that neutrophils play a bidirectional role in periodontal tissue remodeling in mouse periodontitis models. Therefore, targeted regulation of local neutrophil function provides a novel strategy for the treatment of periodontitis.
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