生物活性玻璃
介孔材料
模拟体液
纳米颗粒
材料科学
药物输送
纳米技术
无定形固体
介孔二氧化硅
化学工程
铈
氧化铈
兴奋剂
化学
有机化学
复合材料
氧化物
催化作用
冶金
扫描电子显微镜
光电子学
工程类
作者
Zhiyan Xu,Emily Keller,Ana M. Beltrán,Kai Zheng,Aldo R. Boccaccını
标识
DOI:10.1016/j.jnoncrysol.2023.122578
摘要
Dendritic mesoporous bioactive glass nanoparticles (DMBGNs) with unique three-dimensional structures are attracting increasing attention for biomedical applications. However, it is still challenging to tune the chemical composition of DMBGNs. In this work, we provide for the first time a feasible post-impregnation approach to incorporate metallic ions (Ca and Ce) into dendritic mesoporous silica nanoparticles, resulting in SiO2-CaO and SiO2-CaO-CeO2 (Ce-DMBGNs) without destroying the dendritic mesoporous topography. Both DMBGNs and Ce-DMBGNs were amorphous, negatively charged, with a hydrodynamic size of ∼200 nm. The synthesized DMBGNs and Ce-DMBGNs exhibited high bioactivity as evidenced by the rapid formation of hydroxyapatite (HA) after immersion in simulated body fluid (SBF) for 7 days. In addition, DMBGNs and Ce-DMBGNs showed high propolis loading efficiency and sustained release behavior. The results suggest that the developed Ce-DMBGNs have the potential to be used as a delivery vehicle of therapeutic ions and drugs in bone regeneration applications.
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