光毒性
光动力疗法
系统间交叉
化学
生物医学中的光声成像
组合化学
癌症研究
体外
生物化学
有机化学
医学
物理
核物理学
单重态
光学
激发态
作者
Yuyang Zhang,Min Zhao,Jia Miao,Wei Gu,Jieli Zhu,Baoliang Cheng,Qing Li,Qingqing Miao
出处
期刊:ACS materials letters
[American Chemical Society]
日期:2023-10-20
卷期号:5 (11): 3058-3067
被引量:15
标识
DOI:10.1021/acsmaterialslett.3c00933
摘要
Type I photosensitizers provide great potential for effective antihypoxia cancer treatment because of their low O2 reliance. To achieve tumor specificity, activatable type I photosensitizers that can selectively respond to tumor-related stimuli and thereafter activate their phototoxicity are urgently required, which however are rare. We herein report a hemicyanine-based scaffold with effective type I photoreactions for activatable antihypoxic PDT against tumors. The common hemicyanine (Cy) endows minimized ROS generation, which can be nicely tuned to boost type I ROS production by introducing the halogens to increase the spin–orbit coupling (SOC) constant and thus favor the intersystem crossing (ISC) rate. The optimized CyBr is further modified to achieve an activatable probe (CyBrP) that can specifically unlock its fluoro-photoacoustic signals and phototoxicity upon interaction with alkaline phosphatase (ALP) overexpressed in tumors. By virtue of the high sensitivity and selectivity toward ALP as well as the low O2-dependence of type I ROS generation, CyBrP allows for precise phototheranostics of tumors, leading to effectively suppressed tumor growth in living mice. Therefore, this study presents a facile halogen-substituted strategy to construct hemicyanine-based type I photosensitizers that can serve as universal scaffolds for activatable antihypoxia PDT.
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