Enantioselective C–C, C–halogen and C–H bond forming reactions promoted by organocatalysts based on non-proteinogenic α-amino acid derivatives

The enantioselective organocatalysis is in a continuous progress. This review covers the advances achieved in this area dealing with organocatalysts derived from synthetic peptides and non-proteogenic α-amino acids during the last four years. Here, a special attention is devoted to illustrate the mode of action of the discussed processes according to the frontier orbital theory and DFT calculation analyses, thus giving key mechanistic details.