流行病学
传输(电信)
分子流行病学
星团(航天器)
人类免疫缺陷病毒(HIV)
一般化
人口学
公共卫生
医学
环境卫生
病毒学
生物
基因
计算机科学
内科学
遗传学
病理
社会学
电信
基因型
数学分析
程序设计语言
数学
作者
Jiafeng Zhang,Ke Xu,Jun Jiang,Qin Fan,Xiaobei Ding,Ping Zhong,Hui Xing,Chengliang Chai,Xiaohong Pan
标识
DOI:10.1016/j.ijid.2022.12.033
摘要
This study aimed to establish a collaborative approach to quantify local HIV transmission, which is an issue of great concern to public health.We linked HIV-1 pol gene sequences to demographic information and epidemiological investigations in Hangzhou (a central city in East China). We estimated local acquisition rates from a collaboration of molecular network analysis (with a distance-based approach) and epidemiological investigations.Among 1064 newly diagnosed patients with HIV, 857 pol sequences were acquired and subsequently analyzed. Multiple subtypes were identified, with circulating recombinant form (CRF)07_BC (42.5%) and CRF01_AE (39.2%) predominating, followed by 13 other subtypes and 26 unique recombinant forms. By integrating the molecular network analysis and epidemiological investigations, we estimated that the proportion of local infection was 63.2%. The multivariable analyses revealed that individuals in clusters were more likely to be local residents, be aged 50 years or older, work as farmers, and have a higher first cluster of differentiation 4 count level (P <0.05). The proportions of local acquisitions over 70% were observed in local residents (79.9%, 242/303), individuals aged 50 years or older (73.6%, 181/246), and farmers (75.6%, 99/131).The molecular network analysis can augment traditional HIV epidemic surveillance. This study establishes a paradigm for quantifying local HIV transmission for generalization in other areas.
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