程序性细胞死亡
癌症
癌症研究
癌症治疗
医学
肿瘤科
化学
细胞凋亡
内科学
生物化学
作者
Lingpu Zhang,Nicolás Montesdeoca,Johannes Karges,Haihua Xiao
标识
DOI:10.1002/anie.202300662
摘要
Cancer is one of the deadliest diseases worldwide. Recent statistics have shown that metastases and tumor relapse are the leading causes of cancer-associated deaths. While traditional treatments are able to efficiently remove the primary tumor, secondary tumors remain poorly accessible. Capitalizing on this there is an urgent need for novel treatment modalities. Among the most promising approaches, increasing research interest has been devoted to immunogenic cell death inducing agents that are able to trigger localized cell death of the cancer cells as well as induce an immune response inside the whole organism. Preliminary studies have shown that immunogenic cell death inducing compounds could be able to overcome metastatic and relapsing tumors. Herein, the application of metal complexes as immunogenic cell death inducing compounds is systematically reviewed.
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