苄基异喹啉
化学
对映体
立体化学
乙酰胆碱酯酶
鸟氨酸
延胡索
IC50型
生物化学
酶
体外
生物合成
氨基酸
精氨酸
替代医学
中医药
病理
医学
作者
Sheng Wang,Gui‐Yang Xia,Huan Xia,Xiaohong Wei,Sheng Lin
标识
DOI:10.1016/j.bioorg.2023.106407
摘要
(±)-Yanhusuomide A (1), a novel enantiomeric pair of ornithine-fused benzylisoquinoline, were characterized from the dried tubers of Corydalis yanhusuo, along with a biogenetically related intermediate oblongine (2). Yanhusuomide A features an unprecedented skeleton based on a benzylisoquinoline coupled with an ornithine derivative to form a rare 5,6-dihydro-4H-pyrido[3,4,5-de]quinazoline motif. Plausible biosynthetic pathway of 1 was proposed, and (±)-yanhusuomide A (1) presented potential inhibitory bioactivity against acetylcholinesterase (AChE) with IC50 = 14.07 ± 2.38 μM. The simulation of molecular docking displayed that 1 generated strong interaction with Asp-74 and Trp-86 residues of AChE through attractive charge of the quaternary nitrogen.
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