抗纤维溶解
纤溶亢进
氨甲环酸
医学
血栓造影术
纤溶
氨基己酸
组织纤溶酶原激活剂
外科
麻醉
重症监护医学
内科学
失血
血小板
作者
Daniel Bolliger,Marco Ranucci
标识
DOI:10.1016/j.bja.2024.03.020
摘要
Viscoelastic haemostatic testing (VHT) has been used to determine hyperfibrinolysis and hypofibrinolysis. When modified by addition of tissue plasminogen activator (tPA), VHT has been suggested to assess responses to antifibrinolytic therapy and to estimate the concentration of tranexamic acid in patients undergoing cardiac surgery. Despite some evidence that tPA-modified VHT might allow individualisation of antifibrinolytic therapy, further studies are warranted to prove its clinical benefit for postsurgical bleeding, transfusion of blood products, and thromboembolic events.
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