医学
神经科学
疾病
再生(生物学)
中枢神经系统
叙述性评论
创伤性脑损伤
再生医学
治疗方式
重症监护医学
干细胞
病理
心理学
生物
细胞生物学
遗传学
物理疗法
精神科
作者
Santa Sarma,Dhruva Jyoti Deka,Prakash Rajak,Damiki Laloo,Taposh K. Das,Purbajit Chetia,Dipankar Saha,Alakesh Bharali,Bhargab Deka
出处
期刊:Ibrain
日期:2023-11-30
卷期号:9 (4): 402-420
被引量:2
摘要
Abstract Numerous modalities exist through which the central nervous system (CNS) may sustain injury or impairment, encompassing traumatic incidents, stroke occurrences, and neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Presently available pharmacological and therapeutic interventions are incapable of restoring or regenerating damaged CNS tissue, leading to substantial unmet clinical needs among patients with CNS ailments or injuries. To address and facilitate the recovery of the impaired CNS, cell‐based repair strategies encompass multiple mechanisms, such as neuronal replacement, therapeutic factor secretion, and the promotion of host brain plasticity. Despite the progression of cell‐based CNS reparation as a therapeutic strategy throughout the years, substantial barriers have impeded its widespread implementation in clinical settings. The integration of cell technologies with advancements in regenerative medicine utilizing biomaterials and tissue engineering has recently facilitated the surmounting of several of these impediments. This comprehensive review presents an overview of distinct CNS conditions necessitating cell reparation, in addition to exploring potential biomaterial methodologies that enhance the efficacy of treating brain injuries.
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