CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity

(Cell Reports 42, 113014; August 29, 2023) An incorrect version of the supplemental information was uploaded such that the original version lacked Tables S3, S4, and S5. To make this information available, an updated version that includes these tables is now online. The authors regret this error. CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunityHouse et al.Cell ReportsAugust 20, 2023In BriefHouse, Derrick, et al. develop a reporter cell line through CRISPR-Cas9-mediated “knockin” of GFP cDNA immediately prior to the Cxcl9 stop codon. This enables a CRISPR-Cas9 screen for regulators of CXCL9 to be performed, which identifies IRF1 as a negative regulator of CXCL9 production. Full-Text PDF Open Access