可欣
前蛋白转化酶
枯草杆菌素
PCSK9
医学
肺癌
肿瘤科
内科学
回顾性队列研究
胆固醇
低密度脂蛋白受体
脂蛋白
生物
生物化学
酶
作者
Xiang Gao,Ling Yi,Jinghui Wang,Jinghui Wang,Jinghui Wang,Shucai Zhang
标识
DOI:10.1016/j.jss.2024.06.005
摘要
Curative lung resection remains the key therapeutic strategy for early-stage non-small cell lung cancer (NSCLC). However, a proportion of patients still experience variable outcomes and eventually develop recurrence or die from their disease. Proprotein convertase subtilisin/kexin type 9 (PCSK9) has been identified as a deleterious factor that inhibits tumor cells apoptosis and leads to reduction of lymphocyte infiltration. However, there has been no research on the predicted role of PCSK9 as an immunohistochemical biomarker with survival in resectable NSCLC.
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