Molecular glues that inhibit specific Zn2+-dependent DUB activity and inflammation
炎症
医学
免疫学
作者
Francesca Chandler,Adi Narayana Reddy Poli,Smita Bhutda,Rebecca L. Ross,Miriam Walden,Kieran Walker,Stefano Di Donato,Joel Cassel,Michaël Prakesch,Ahmed Aman,Alessandro Datti,Lisa J. Campbell,Martina Foglizzo,Lillie Bell,Daniel N Stein,James R. Ault,Rima Al‐awar,Antonio N. Calabrese,Frank Sicheri,Francesco Del Galdo,Joseph M. Salvino,Roger A. Greenberg,Elton Zeqiraj
Deubiquitylases (DUBs) play a pivotal role in cell signalling and are often regulated by homo- or hetero-interactions within protein complexes. The BRCC36 isopeptidase complex (BRISC) regulates inflammatory signalling by selectively cleaving K63-linked polyubiquitin chains on Type I interferon receptors (IFNAR1). BRCC36 is a Zn
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