皮诺森布林
信号转导
化学
细胞生物学
药理学
生物
生物化学
抗氧化剂
类黄酮
作者
Yilin Wu,Ting Hu,Hong Zheng,Jifeng Feng,Chen‐Wei Huang,Xiao-Na Zhou,Wei Wang,Chun‐Lei Jiang
标识
DOI:10.1016/j.bbrc.2024.150870
摘要
Depression, a prevalent and severe mental disorder, continues to be a significant area of research concerning its pathogenesis and therapeutic approaches. Conventional antidepressants are often limited by delayed therapeutic effects and notable adverse reactions, necessitating the development of innovative and efficacious treatment modalities. Multiple lines of evidence suggest that peripheral and central inflammation play a role in depression, and that anti-inflammatory drugs can ameliorate depressive symptoms in patients with inflammation-related depression. Pinocembrin (PB), a natural bioactive compound, is renowned for its anti-inflammatory and antioxidant properties, while the effect and mechanism of PB are still unclear. Consequently, this study employs PB as an intervention to investigate its effects on depression in mice model, with the objective of establishing a novel therapeutic strategy and foundational data for the treatment of depression.
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