Synthesis and biological evaluation of novel coumarin derivatives bearing sulfonamide moiety in antiviral and antibacterial agent

20 novel 4-bromine-coumarin derivatives bearing sulfonamide moiety were designed and synthesized. Their antiviral activities and antibacterial were systematically evaluated. The test results show that all the target compounds possess moderate to excellent antiviral and antibacterial activities. Among all target compounds, compound I15 exhibited good antiviral activity against TMV, CMV, PVY. Which is superior to ribavirin. Moreover, target compounds I8 and I15 exhibited good in vitro antibacterial activity against Psa, with an EC50 value of 44.9 mg/L, 49.3 mg/L, respectively, which were better than thiodiazole copperand and zinc thiazoles, with an EC50 value of 56.3 mg/L, 50.2 mg/L, respectively. The results provides insights for the development of multi-functional pesticides.