前药
光动力疗法
壳聚糖
纳米颗粒
化学
纳米技术
药理学
材料科学
医学
有机化学
生物化学
作者
Jingmou Yu,Бо Лю,Chen‐Yu Zhang,Lizhen Cheng,Chuqi Peng,Dengzhao Jiang,Wenbo Liu,Hong‐Guang Jin,Jin Ren
标识
DOI:10.1080/10837450.2024.2411027
摘要
Herein, we designed and synthesized novel reactive oxygen species (ROS)-responsive glycol chitosan-doxorubicin (DOX) prodrug via a ROS-cleavable thioketal (TK) linker. The obtained GC-TK-DOX formed self-assembled nanoparticles of 312 nm in aqueous media. Photosensitizers zinc phthalocyanine (ZnPc)-loaded GC-TK-DOX (GC-TK-DOX/ZnPc) nanoparticles were fabricated by using a dialysis approach. The GC-TK-DOX and GC-TK-DOX/ZnPc nanoparticles were nearly spherical by transmission electron microscopy (TEM) observation. Under 660-nm laser irradiation, GC-TK-DOX/ZnPc could generate singlet oxygen. Further, GC-TK-DOX/ZnPc nanoparticles exhibited ROS-sensitive release of DOX and ZnPc
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