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Association of Medication Adherence and Health Status in Heart Failure With Reduced Ejection Fraction: Insights From the CHAMP-HF Registry

医学 射血分数 心力衰竭 混淆 生活质量(医疗保健) 内科学 指南 临床终点 物理疗法 随机对照试验 护理部 病理
作者
Rayan El‐Zein,Moghniuddin Mohammed,Dan Nguyen,C. Larry Hill,Laine Thomas,Michael E. Nassif,Adam D. DeVore,Nancy M. Albert,Javed Butler,J. Herbert Patterson,Fredonia B. Williams,Adrian F. Hernandez,Gregg C. Fonarow,John A. Spertus
出处
期刊:Circulation-cardiovascular Quality and Outcomes [Ovid Technologies (Wolters Kluwer)]
标识
DOI:10.1161/circoutcomes.123.010211
摘要

BACKGROUND: The foundation for managing heart failure with reduced ejection fraction (HFrEF) is adherence to guideline-directed medical therapy. Finding an association between medication adherence and patients’ health status (their symptoms, function, and quality of life) can be used to underscore its importance to patients. METHODS: The association of self-reported medication adherence in US outpatients with HFrEF enrolled in the Change the Management of Patients with Heart Failure registry from 2015 to 2017 was compared with their health status at baseline and 12 months later. A secondary analysis of changes in adherence between baseline and 6 months with 6-month health status was also performed. Medication adherence was assessed with the self-reported 4-item Morisky-Green-Levine Medication Adherence Scale, with scores ≥1 classified as nonadherent. The primary health status outcome was the disease-specific 12-item Kansas City Cardiomyopathy Questionnaire Overall Summary Score (KCCQ-OS; range, 0–100; higher is better). Robust linear regression models adjusted for confounders were used. RESULTS: After excluding those who died (n=316) or did not provide 12-month KCCQ (n=1285), 3495 outpatients with HFrEF were included, of whom 1108 (31.7%) reported being nonadherent. Nonadherent participants were younger, had significantly worse baseline health status (−5.83-point difference; P <0.001), and showed less improvement at 12 months (−1.7-point difference in mean change; P =0.017) than adherent participants. Among nonadherent patients at baseline, those whose adherence improved trended toward greater 6-month health status improvements than those remaining nonadherent (fully adjusted difference of 2.52 points; P =0.054). CONCLUSIONS: In HFrEF, medication nonadherence was associated with worse health status and less improvement over the following year. Improvements in adherence were associated with better health status than remaining nonadherent, underscoring the importance of supporting adherence with guideline-directed medical therapy in patients with HFrEF.
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