群体感应
多重耐药
抗菌剂
抗生素耐药性
人类病原体
人类健康
生物膜
微生物学
生物
抗药性
细菌
医学
抗生素
遗传学
环境卫生
作者
A P Cardiliya,Anthonymuthu Selvaraj,M. J. Nanjan,M Chandrasekar
出处
期刊:Mini-reviews in Medicinal Chemistry
[Bentham Science]
日期:2022-06-01
卷期号:22 (10): 1380-1394
被引量:1
标识
DOI:10.2174/1389557521666211101155150
摘要
: The existence of multidrug–resistant (MDR) E. coli (superbugs) is a global health issue confronting humans, livestock, food processing units, and pharmaceutical industries. The quorum sensing (QS) controlling ability of the E. coli to form biofilms has become one of the important reasons for the emergence of multidrug-resistant pathogens. Quorum signaling activation and formation of biofilm lead to the emergence of antimicrobial resistance of the pathogens increasing the therapy difficult for treating bacterial diseases. There is a crucial need, therefore, to reinforce newer therapeutic designs to overcome this resistance. As the infections caused by E. coli are attributed via the QSregulated biofilm formation, easing this system by QS inhibitors is a possible strategy for treating bacterial diseases. Plant based natural products have been reported to bind to QS receptors and interrupt the QS systems of pathogens by inhibiting biofilm formation and disrupting the formed biofilms, thus minimizing the chances to develop a resistance mechanism. The present report reviews critically the QS capability of E. coli to form biofilms leading to multidrug resistant pathogens and the investigations that have been carried out so far on plant acquired natural products as QS inhibitors.
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