Enhanced stability of stilbene-glycoside-loaded nanoparticles coated with carboxymethyl chitosan and chitosan hydrochloride

Stilbene-glycoside (THSG) is a promising dietary supplement with remarkable biological properties, however, its poor stability and low oral bioavailability hinder its application as an ingredient in functional foods. Herein, stilbene-glycoside-loaded nanoparticles (THSG-NPs) coated with carboxymethyl chitosan (CMC) and chitosan hydrochloride (CHC) using a complex coacervation method were successfully prepared for enhancing the stability of THSG. The optimized preparation parameters were 2.5 mg/mL CMC, 1.0 mg/mL CHC, 1.5 mg/mL THSG and preparation temperature of 25 °C, under which the experimentally designed particles averaged 381.9 nm with encapsulation efficiency (EE) of 68.6%. Solid-state characterization was assessed by Fourier transform infrared spectroscope and Differential scanning calorimetry. THSG-NPs showed significant protective effects against heat and solar radiation and exhibited remarkable pH-dependent and controlled release. This work demonstrated that enhanced stability and delayed release of THSG could be achieved using THSG-NPs, which could contribute to its potential application in the functional foods industry.