A first-in-human phase I study of ATR inhibitor M1774 in patients with solid tumors.
临床研究阶段
内科学
药代动力学
耐受性
毒性
作者
Timothy A. Yap,Anthony W. Tolcher,Elizabeth Ruth Plummer,Andreas Becker,Patricia Fleuranceau-Morel,Thomas Goddemeier,Giuseppe Locatelli,Ioannis Gounaris,Johann S. de Bono
TPS3153Background: Ataxia telangiectasia and Rad3-related (ATR) protein kinase plays a critical role in the DNA damage response by sensing and responding to DNA replication stress, and by inducing ...
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