毛螺菌科
蔷薇花
生物
肠道菌群
益生菌
微生物学
腹泻
抗生素
抗生素相关性腹泻
真细菌
免疫学
拟杆菌
细菌
16S核糖体RNA
厚壁菌
医学
内科学
遗传学
艰难梭菌
作者
Huang Darong,Yanlan Chen,Hongzhu Chen,Xinyu Deng,Jianzhao Huang,Shu‐Ling Lu,Pan Li,Bing Du
标识
DOI:10.1007/s12602-022-09906-8
摘要
Bacillus sp. DU-106, a potential probiotic, has been proved to activate innate immunity, reduce hypercholesterolemia, and regulate the gut microbiota of mice. In the present study, we investigated the therapeutic effect of strain DU-106 in antibiotic-associated diarrhea (AAD) via analyzing the changes in gut microbial composition in mice. The results indicated that supplementation of strain DU-106 alleviated gastrointestinal symptoms, improved gut barrier integrity and immunoglobulin-A level of mice with AAD. A 16S rRNA sequencing showed that antibiotics decreased bacterial diversity and the abundances of Alistipes, Roseburia, Hungatella, Eubacterium-xylanophilum, Lachnospiraceae-UCG-001, Intestinimonas, and Lachnospiraceae-NK4A136, but increased the abundance of Klebsiella, Bacteroidota, and Verrucomicrobiota. However, strain DU-106 treatment reversed these alternations in mice with AAD. In conclusion, strain DU-106 could alleviate AAD in association with the regulation of intestinal microbiota and could be used as an alternative treatment for AAD.
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