Responders to Sodium-Glucose Cotransporter 2 Inhibitors in Improving Left Ventricular Function

医学 射血分数 内科学 心力衰竭 心脏病学 心功能曲线 舒张期 糖尿病 队列 肾功能 内分泌学 血压
作者
Masaki Nakagaito,Robert A. Berg,Shuji Joho,Ryuichi Ushijima,Makiko Nakamura,Koichiro Kinugawa
出处
期刊:International Heart Journal [Japanese Heart Journal Assoc]
卷期号:63 (3): 550-557
标识
DOI:10.1536/ihj.22-027
摘要

Sodium-glucose cotransporter 2 inhibitor (SGLT2i)-incorporated medical therapy is associated with cardiac function improvement in patients with heart failure. However, the factors associated with such an improvement remain unknown.This study included patients with heart failure and type 2 diabetes mellitus who received SGLT2i-incorporated medical therapy in our institute. Transthoracic echocardiography was performed at baseline and 3-18 months later. The factors associated with cardiac function improvement were investigated.A total of 47 patients (median age, 69 years old; 35 men) were included in this study. SGLT2i was administered for median 284 days (range: 86-730 days). The left ventricular ejection fraction increased from 39.0% to 54.0% (P < 0.001), and the E/e' ratio decreased from 14.0 to 10.4 (P = 0.002). Younger age, higher serum albumin level, and lower serum sodium level were independently associated with an improvement in systolic function, defined as an increase in the ejection fraction of ≥ 35% among patients with systolic heart failure (P = 0.018). Male sex and impaired renal function tended to be associated with an improvement in diastolic function, defined as a decrease in the E/e' ratio of ≥ 20% among the overall cohort.Several factors were associated with improvements in systolic and diastolic functions during the SGLT2i-incorporated medical therapy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
今后应助拼搏的潘子采纳,获得10
1秒前
1秒前
CipherSage应助俏皮的飞烟采纳,获得30
2秒前
孟小茶发布了新的文献求助10
2秒前
研友_LBRPOL完成签到,获得积分10
2秒前
畅快的寄松完成签到,获得积分10
3秒前
温暖白秋完成签到,获得积分10
3秒前
量子星尘发布了新的文献求助10
3秒前
情怀应助忧伤的元菱采纳,获得10
3秒前
仲达发布了新的文献求助10
4秒前
欣欣欣欣完成签到,获得积分10
6秒前
沈竑宇发布了新的文献求助10
7秒前
7秒前
杭问兰发布了新的文献求助10
8秒前
JW完成签到,获得积分10
9秒前
星辰大海应助Kuma采纳,获得30
9秒前
呆哈哈完成签到 ,获得积分10
10秒前
11秒前
啦啦咔嘞完成签到,获得积分10
12秒前
12秒前
我是老大应助YKH采纳,获得10
12秒前
可爱奇异果完成签到 ,获得积分10
13秒前
魔王完成签到,获得积分10
14秒前
溜达鸡关注了科研通微信公众号
14秒前
15秒前
啦啦咔嘞发布了新的文献求助10
15秒前
15秒前
15秒前
今后应助shinn采纳,获得30
15秒前
隐形曼青应助白藏采纳,获得10
16秒前
16秒前
16秒前
16秒前
gang发布了新的文献求助10
16秒前
17秒前
香蕉飞饼完成签到 ,获得积分10
17秒前
19秒前
mof发布了新的文献求助10
20秒前
金豆子发布了新的文献求助10
20秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975375
求助须知:如何正确求助?哪些是违规求助? 3519700
关于积分的说明 11199305
捐赠科研通 3256034
什么是DOI,文献DOI怎么找? 1798049
邀请新用户注册赠送积分活动 877386
科研通“疑难数据库(出版商)”最低求助积分说明 806305