抄写(语言学)
抑制因子
转录因子
真核转录
DNA
基因
细胞生物学
DNA结合蛋白
一般转录因子
电箱
GATAD2B型
生物
化学
发起人
生物化学
增强子
基因表达
语言学
哲学
作者
Liam P. Keegan,Grace Gill,Mark Ptashne
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1986-02-14
卷期号:231 (4739): 699-704
被引量:606
标识
DOI:10.1126/science.3080805
摘要
The yeast GAL4 protein (881 amino acids) binds to specific DNA sites upstream of target genes and activates transcription. Derivatives of this protein bearing as few as 74 amino terminal residues bind to these sites but fail to activate transcription. When appropriately positioned in front of a gene these derivatives act as repressors. These and related findings support the idea that GAL4 activates transcription by touching other DNA-bound proteins.
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