The Origin of Ovarian Carcinomas

间皮 上皮 生物 输卵管 移行上皮 病理 壶腹 肿瘤转化 恶性转化 解剖 癌症研究 癌变 内分泌学 癌症 医学 遗传学 大肠杆菌 腹膜 基因
作者
Nelly Auersperg
出处
期刊:International Journal of Gynecological Pathology [Lippincott Williams & Wilkins]
卷期号:30 (1): 12-21 被引量:127
标识
DOI:10.1097/pgp.0b013e3181f45f3e
摘要

It is currently a controversial issue whether epithelial ovarian cancers arise in the ovarian surface epithelium (OSE) or the fimbrial epithelium of the oviduct. The hypothesis presented here aims to reconcile these 2 views and provides a possible explanation for 2 questions arising: first, why tumors originating in the fimbriae and OSE, which are parts of different organs, express common features; second, why these epithelia are prone to neoplastic transformation whereas the remaining oviduct and the extraovarian mesothelium are not. We hypothesize that these questions relate to the common origin of the OSE and fimbriae in that region of the embryonic coelomic epithelium, which will eventually link the extraovarian mesothelium to the epithelium of the oviductal ampulla. OSE and fimbriae become separated during embryonic development but, like other transitional, interepithelial junctions in adults, this region might remain incompletely committed and thus prone to neoplastic progression. To define differentiation at the OSE-tubal junction, salpingo-oophorectomy specimens were stained immunohistochemically for mesenchymal differentiation markers of OSE and for epithelial markers and Pax8, characterizing oviductal fimbriae and ampullae. OSE and ampullae were distinctly different, but there was no sharp boundary between OSE and fimbriae. Rather, both mesenchymal and epithelial markers overlapped, and Pax8 and fimbrial epithelial markers diminished distally, near the OSE. The results support the hypothesis that the OSE and fimbriae are parts of a transitional epithelium of common origin rather than 2 independent sources of ovarian cancer, and suggest that their immature, incompletely determined phenotype contributes to their propensity to neoplastic transformation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
大橙子发布了新的文献求助10
3秒前
wzhang完成签到,获得积分10
4秒前
ken131完成签到 ,获得积分10
7秒前
myl完成签到,获得积分10
8秒前
728完成签到,获得积分10
14秒前
xiaofeng5838完成签到,获得积分10
14秒前
ronnie完成签到,获得积分10
14秒前
17秒前
寒冷芷蕊完成签到,获得积分20
17秒前
17秒前
Jane完成签到,获得积分10
17秒前
一氧化二氢完成签到,获得积分10
23秒前
凡事发生必有利于我完成签到,获得积分10
24秒前
yihaiqin完成签到 ,获得积分10
28秒前
轩辕剑身完成签到,获得积分0
28秒前
coolkid完成签到 ,获得积分0
29秒前
你怎么那么美完成签到,获得积分10
29秒前
游艺完成签到 ,获得积分10
32秒前
冬月完成签到 ,获得积分10
32秒前
薛乎虚完成签到 ,获得积分10
33秒前
34秒前
大胖完成签到,获得积分10
34秒前
野火197完成签到,获得积分10
38秒前
39秒前
量子星尘发布了新的文献求助10
42秒前
April完成签到,获得积分10
42秒前
周舟完成签到 ,获得积分10
45秒前
V_I_G完成签到 ,获得积分10
46秒前
nick完成签到,获得积分10
47秒前
高高高完成签到 ,获得积分10
50秒前
彪壮的亦瑶完成签到 ,获得积分10
51秒前
科研通AI2S应助科研通管家采纳,获得10
53秒前
Perry应助科研通管家采纳,获得60
53秒前
Akim应助科研通管家采纳,获得10
53秒前
鱼雷完成签到,获得积分10
54秒前
廿伊发布了新的文献求助10
56秒前
我是125完成签到,获得积分10
58秒前
依人如梦完成签到 ,获得积分10
59秒前
1分钟前
PDIF-CN2完成签到,获得积分10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038157
求助须知:如何正确求助?哪些是违规求助? 3575869
关于积分的说明 11373842
捐赠科研通 3305650
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022