Radiofrequency Energy and Electrode Proximity Influences Stereoelectroencephalography-Guided Radiofrequency Thermocoagulation Lesion Size: An In Vitro Study with Clinical Correlation

立体脑电图 射频热凝 发作性 医学 病变 射频消融术 磁共振成像 放射科 癫痫 核医学 脑电图 生物医学工程 病理 烧蚀 内科学 精神科 经皮
作者
Michael D. Staudt,Sarita Maturu,Jonathan P. Miller
出处
期刊:Operative Neurosurgery [Lippincott Williams & Wilkins]
卷期号:15 (4): 461-469 被引量:13
标识
DOI:10.1093/ons/opx291
摘要

Abstract BACKGROUND Radiofrequency thermocoagulation of epileptogenic foci via stereoelectroencephalography (SEEG) electrodes has been suggested as a treatment for medically intractable epilepsy, but reported outcomes have been suboptimal, possibly because lesions generated using conventional high-energy radiofrequency parameters are relatively small. OBJECTIVE To describe a technique of delivering low energy across separate SEEG electrodes in order to create large confluent radiofrequency lesions. METHODS The size and configuration of radiofrequency lesions using different radiofrequency intensity and interelectrode distance was assessed in egg whites. Magnetic resonance images (MRI) from 3 patients who had undergone radiofrequency lesion creation were evaluated to determine the contribution of lesion intensity and electrode separation on lesion size. Electroencephalography, MRI, and clinical data were assessed before and after lesion creation. RESULTS Both in Vitro and in Vivo analysis revealed that less energy paradoxically produced larger lesions, with the largest possible lesions produced when radiofrequency power was applied for long duration at less than 3 W. Linear separation of electrodes also contributed to lesion size, with largest lesions produced when electrodes were separated by a linear distance of between 5 and 12 mm. Clinical lesions produced using these parameters were large and resulted in improvement in interictal and ictal activity. CONCLUSION Radiofrequency lesions produced using low-energy delivery between SEEG electrodes in close proximity can produce a large lesion. These findings might have advantages for treatment of focal epilepsy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
深情安青应助leisurelft采纳,获得10
1秒前
ddd完成签到,获得积分10
1秒前
LQQ发布了新的文献求助10
1秒前
1秒前
852应助有魅力小刺猬采纳,获得10
2秒前
星辰大海应助xinchengzhu采纳,获得10
2秒前
仁爱的小懒猪完成签到 ,获得积分10
2秒前
3秒前
May发布了新的文献求助10
3秒前
3秒前
ly完成签到,获得积分20
3秒前
所所应助愉快的芒果采纳,获得10
4秒前
Coco完成签到,获得积分10
4秒前
4秒前
木桶饭团完成签到,获得积分10
4秒前
myt发布了新的文献求助10
4秒前
埃特纳氏完成签到 ,获得积分10
5秒前
vic303发布了新的文献求助10
5秒前
量子星尘发布了新的文献求助10
6秒前
国王的指环1111完成签到,获得积分10
6秒前
我是老大应助呵浅陌采纳,获得10
7秒前
jliu发布了新的文献求助10
7秒前
7秒前
Chochee完成签到,获得积分10
8秒前
8秒前
10秒前
打打应助会飞的猪采纳,获得10
10秒前
Real_ora完成签到,获得积分10
11秒前
iNk应助怡然思萱采纳,获得20
11秒前
幸福的白柏完成签到,获得积分10
12秒前
朴实夏旋发布了新的文献求助10
13秒前
13秒前
仇湘完成签到,获得积分10
13秒前
Marybaby发布了新的文献求助10
13秒前
Ha完成签到,获得积分10
13秒前
13秒前
认真乐双完成签到,获得积分10
14秒前
14秒前
罗中翠完成签到,获得积分10
15秒前
yanshapo发布了新的文献求助10
15秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Social Research Methods (4th Edition) by Maggie Walter (2019) 2390
A new approach to the extrapolation of accelerated life test data 1000
北师大毕业论文 基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 390
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4009871
求助须知:如何正确求助?哪些是违规求助? 3549812
关于积分的说明 11303839
捐赠科研通 3284342
什么是DOI,文献DOI怎么找? 1810591
邀请新用户注册赠送积分活动 886393
科研通“疑难数据库(出版商)”最低求助积分说明 811406