FOXP3型
白细胞介素2受体
人参
调节性T细胞
人参皂甙
免疫系统
细胞分化
细胞生物学
移植
免疫学
免疫耐受
细胞
生物
T细胞
化学
医学
生物化学
内科学
基因
替代医学
病理
作者
Jisu Kim,Hyeyoung Byeon,Kyungtaek Im,Hye‐Young Min
标识
DOI:10.1007/s10068-017-0255-3
摘要
Regulatory T cells (Treg cells) are a subpopulation of T cells defined as CD4+Foxp3+CD25+. They mainly function as immunosuppressive T cells by downregulating the induction and proliferation of effector T cells, but also modulate the immune system by maintaining self-tolerance and preventing autoimmune disease. In this study, the regulatory roles of ginsenosides, one of the active components in ginseng, Panax ginseng C. A. Meyer, in Treg cell differentiation were examined. The results demonstrated that ginsenoside Rd induced Treg differentiation by upregulating Foxp3 expression and increased the generation of TGF-β1, IL-10 and IL-35. The data suggest that ginsenoside Rd may be a potential immunomodulating agent or supplement that can be applied for transplantation and autoimmune disorders.
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