Abstract Although organizational change often places strain on employees, few studies have explored the impact of multiple organizational changes on their well-being and withdrawal, including organizational commitment and turnover intentions. To provide a means of directly investigating such issues, we developed a measure of change fatigue, and then empirically examined its implications for employees. Using data from change consultants and a manufacturing organization in the United States that had undertaken a number of organizational changes over the last three years, the authors developed a six-item measurement scale, obtained initial evidence of construct validity, and then investigated the relationship between change fatigue and harmful outcomes, including exhaustion, organizational commitment and turnover intentions. Results indicated that change fatigue was positively associated with exhaustion, and exhaustion was in turn negatively related to organizational commitment and positively related to turnover intentions. Implications for organizations and employees facing multiple changes are discussed.