Transglutaminase (TGase) is widely applied in the meat industry, and mixing of meat from various sources is an efficient way to enhance the quality of meat products. In this study, sensory scores, color, gel properties, water holding capacity and microstructure of mince mixtures, treated with 0.4% TGase, were determined to investigate the effect of TGase and mixing ratios (pork/fish, 10:0, 7:3, 5:5, 3:7, 0:10) on quality and gel properties of mince mixtures composed of pork and silver carp (Hypophthalmichthys molitrix). Results indicated that the mixture improved the sensory quality and gel properties of meat products compared to control group. The addition of TGase significantly (p < .05) increased the gel strength, especially at 7:3 ratio of pork and silver carp, in which gel strength reached its maximum and was 10.26%, 64.15% greater than pork with TGase and without TGase respectively, and water holding capacity were greater, and microstructure became more compact. The results suggest the synergetic interaction between proteins of pork and silver carp. TGase increased the interaction, especially for mixing proportion of 7:3 (pork/fish). Those results could be useful for the development of mixed and new meat products in the food industry.Pork and silver carp are two main meat in diet, and mince mixtures can improve the nutrition of meat product. TGase is usually used to enhance the texture and gel properties of meat in industry. The addition of TGase in pork/fish mince mixtures can not only improve the texture, but catalyze the synergetic interaction between proteins from different meat and further enhance gel properties of mice mixtures in a certain ratio. All of that will provide reference for meat processing and development of new meat product.