亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

How patient-specific do internal carotid artery inflow rates need to be for computational fluid dynamics of cerebral aneurysms?

颈内动脉 流入 医学 波形 脉动流 计算流体力学 动脉瘤 心脏病学 血流 血流动力学 内科学 外科 机械 物理 量子力学 电压
作者
Mehdi Najafi,Nicole M Cancelliere,Olivier Brina,Pierre Bouillot,María Isabel Vargas,Bénédicte MA Delattre,Vítor Mendes Pereira,David A. Steinman
出处
期刊:Journal of NeuroInterventional Surgery [BMJ]
卷期号:13 (5): 459-464 被引量:19
标识
DOI:10.1136/neurintsurg-2020-015993
摘要

Background Computational fluid dynamics (CFD) has become a popular tool for studying ‘patient-specific’ blood flow dynamics in cerebral aneurysms; however, rarely are the inflow boundary conditions patient-specific. We aimed to test the impact of widespread reliance on generalized inflow rates. Methods Internal carotid artery (ICA) flow rates were measured via 2D cine phase-contrast MRI for 24 patients scheduled for endovascular therapy of an ICA aneurysm. CFD models were constructed from 3D rotational angiography, and pulsatile inflow rates imposed as measured by MRI or estimated using an average older-adult ICA flow waveform shape scaled by a cycle-average flow rate (Q avg ) derived from the patient’s ICA cross-sectional area via an assumed inlet velocity. Results There was good overall qualitative agreement in the magnitudes and spatial distributions of time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI), and spectral power index (SPI) using generalized versus patient-specific inflows. Sac-averaged quantities showed moderate to good correlations: R 2 =0.54 (TAWSS), 0.80 (OSI), and 0.68 (SPI). Using patient-specific Q avg to scale the generalized waveform shape resulted in near-perfect agreement for TAWSS, and reduced bias, but not scatter, for SPI. Patient-specific waveform had an impact only on OSI correlations, which improved to R 2 =0.93. Conclusions Aneurysm CFD demonstrates the ability to stratify cases by nominal hemodynamic ‘risk’ factors when employing an age- and vascular-territory-specific recipe for generalized inflow rates. Q avg has a greater influence than waveform shape, suggesting some improvement could be achieved by including measurement of patient-specific Q avg into aneurysm imaging protocols.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
6秒前
英姑应助科研通管家采纳,获得10
8秒前
打打应助科研通管家采纳,获得10
8秒前
8秒前
24124f发布了新的文献求助10
11秒前
19秒前
34秒前
36秒前
大闲鱼铭一完成签到 ,获得积分10
37秒前
干净涵梅发布了新的文献求助10
42秒前
舒适的藏花完成签到 ,获得积分10
45秒前
49秒前
boogie发布了新的文献求助10
57秒前
testmanfuxk完成签到,获得积分10
1分钟前
1分钟前
polelight发布了新的文献求助30
1分钟前
boogie完成签到,获得积分20
1分钟前
wdy111应助云缘之芒采纳,获得50
1分钟前
1分钟前
小付发布了新的文献求助10
1分钟前
1分钟前
1分钟前
红橙黄绿蓝靛紫111完成签到,获得积分10
1分钟前
cy0824完成签到 ,获得积分10
1分钟前
yyy完成签到 ,获得积分10
1分钟前
SciGPT应助科研通管家采纳,获得10
2分钟前
失眠奥特曼完成签到,获得积分10
2分钟前
2分钟前
李李发布了新的文献求助10
2分钟前
李李完成签到,获得积分20
2分钟前
刘宇童完成签到,获得积分10
2分钟前
2分钟前
Jasper应助李李采纳,获得10
3分钟前
chenting完成签到 ,获得积分10
3分钟前
小付完成签到,获得积分10
3分钟前
NexusExplorer应助科研通管家采纳,获得10
4分钟前
烟消云散完成签到,获得积分10
4分钟前
汉堡包应助梦梦采纳,获得10
4分钟前
4分钟前
Orange应助reerwt采纳,获得10
4分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990049
求助须知:如何正确求助?哪些是违规求助? 3532108
关于积分的说明 11256354
捐赠科研通 3270976
什么是DOI,文献DOI怎么找? 1805166
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228